Protein tetrazinylation via diazonium coupling for covalent and catalyst-free bioconjugation.
نویسندگان
چکیده
An efficient and bench-stable reagent was synthesized for direct and covalent introduction of tetrazines onto target protein or virus surfaces, which can be further modified based on tetrazine-ene ligation to achieve fluorescence labelling or PEGylation under mild conditions.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 47 شماره
صفحات -
تاریخ انتشار 2015